Main Menu (Mobile)- Block

Main Menu - Block

Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.

Our Research / Publications
janelia7_blocks-janelia7_biblio_header | block
Genes, Brain, and Behavior. 2008 Aug;7(6):669-76. doi: 10.1111/j.1601-183X.2008.00404.x
View Article on
Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Heberlein Lab
Kapfhamer D, Bettinger JC, Davies AG, Eastman CL, Smail EA, Heberlein U, McIntire SL
Note: Research in this publication was not performed at Janelia.
janelia7_blocks-janelia7_biblio_abstract | block

Abstract

The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor AEX-3 confer resistance to the acute locomotor effects of ethanol. Similarly, mice lacking one or both copies of Rab3A are resistant to the ataxic and sedative effects of ethanol, and Rab3A haploinsufficiency increases voluntary ethanol consumption. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.

PMID: 18397381 [PubMed - indexed for MEDLINE]

node:body | entity_field
janelia7_blocks-janelia7_biblio_authors | block

Janelia Authors

Ulrike Heberlein
janelia7_blocks-janelia7_biblio_tools | block