Modulation of calcium signaling “on demand” to decipher the molecular mechanisms responsible for primary aldosteronism

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Archives of Cardiovascular Diseases Supplements. 2023 May 01;15(2):188. doi: 10.1016/j.acvdsp.2023.03.021

Modulation of calcium signaling “on demand” to decipher the molecular mechanisms responsible for primary aldosteronism Sternson Lab

Fedlaoui B, Cosentino T, Sayed ZR, Fernandes-Rosa FL, Hulot J, Magnus C, Sternson SM, Travers-Allard S, Baron S, Giscos-Douriez I, Zennaro MC, Boulkroun S

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Abstract

Primary aldosteronism (PA) is the most frequent form of secondary hypertension. Over the past two decades, major advances have been made in our understanding of the disease with the identification of germline or somatic mutations in ion channels and pumps. These mutations enhance calcium signaling, the main trigger of aldosterone biosynthesis.

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Modulation of calcium signaling “on demand” to decipher the molecular mechanisms responsible for primary aldosteronism

Abstract

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