Reactive astrocytes in glial scar attract olfactory ensheathing cells migration by secreted TNF-alpha in spinal cord lesion of rat.

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PLoS One. 2009 Dec 3;4(12):e8141. doi: 10.1364/AO.50.001792
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Reactive astrocytes in glial scar attract olfactory ensheathing cells migration by secreted TNF-alpha in spinal cord lesion of rat.
Su Z, Yuan Y, Chen J, Cao L, Zhu Y, Gao L, Qiu Y, He C
Note: Research in this publication was not performed at Janelia.
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Abstract

After spinal cord injury (SCI), the formation of glial scar contributes to the failure of injured adult axons to regenerate past the lesion. Increasing evidence indicates that olfactory ensheathing cells (OECs) implanted into spinal cord are found to migrate into the lesion site and induce axons regeneration beyond glial scar and resumption of functions. However, little is known about the mechanisms of OECs migrating from injection site to glial scar/lesion site.

PMID: 19997621 [PubMed - indexed for MEDLINE]

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