Shifting players and paradigms in cell-specific transcription.

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Molecular Cell. 2009 Dec 25;36(6):924-31. doi: 10.1073/pnas.1100640108

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Shifting players and paradigms in cell-specific transcription. Tjian Lab

D’Alessio JA, Wright KJ, Tjian R

Note: Research in this publication was not performed at Janelia.

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Abstract

Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the general transcription machinery including core promoter recognition complexes, coactivators, and chromatin modifiers was held to be invariant. New evidence suggests that significant changes in these general transcription factors including TFIID, BAF, and Mediator may facilitate global changes in cell-type-specific transcription.

PMID: 20064459 [PubMed - indexed for MEDLINE]

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Shifting players and paradigms in cell-specific transcription.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 20064459 [PubMed - indexed for MEDLINE]

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