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The Neuropixels probe: A CMOS based integrated microsystems platform for neuroscience and brain-computer interfaces.

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2019 IEEE International Electron Devices Meeting (IEDM). 2020 Feb 13;. doi: 10.1109/IEDM19573.201910.1109/IEDM19573.2019.8993611
The Neuropixels probe: A CMOS based integrated microsystems platform for neuroscience and brain-computer interfaces. Harris Lab
Dutta B, Trautmann EM, Welkenhuysen M, Shenoy KV, Andrei A, Harris TD, Lopez CM, O'Callahan J, Putzeys J, Raducanu BC, Severi S, Stavisky SD
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Abstract

We review recent progress in neural probes for brain recording, with a focus on the Neuropixels platform. Historically the number of neurons’ recorded simultaneously, follows a Moore’s law like behavior, with numbers doubling every 6.7 years. Using traditional techniques of probe fabrication, continuing to scale up electrode densities is very challenging. We describe a custom CMOS process technology that enables electrode counts well beyond 1000 electrodes; with the aim to characterize large neural populations with single neuron spatial precision and millisecond timing resolution. This required integrating analog and digital circuitry with the electrode array, making it a standalone integrated electrophysiology recording system. Input referred noise and power per channel is 7.5µV and <50µW respectively to ensure tissue heating <1°C. This approach enables doubling the number of measured neurons every 12 months.

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Janelia Authors

Tim Harris
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