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1 Janelia Publications

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    Spruston Lab
    05/02/23 | Meta-learning in head fixed mice navigating in virtual reality: A Behavioral Analysis
    Xinyu Zhao , Rachel Gattoni , Andrea Kozlosky , Angela Jacobs , Colin Morrow , Sarah Lindo , Nelson Spruston
    bioRxiv. 2023 May 02:. doi: 10.1101/2023.05.01.538936

    Animals can learn general task structures and use them to solve new problems with novel sensory specifics. This capacity of ‘learning to learn’, or meta-learning, is difficult to achieve in artificial systems, and the mechanisms by which it is achieved in animals are unknown. As a step toward enabling mechanistic studies, we developed a behavioral paradigm that demonstrates meta-learning in head-fixed mice. We trained mice to perform a two-alternative forced-choice task in virtual reality (VR), and successively changed the visual cues that signaled reward location. Mice showed increased learning speed in both cue generalization and serial reversal tasks. During reversal learning, behavior exhibited sharp transitions, with the transition occurring earlier in each successive reversal. Analysis of motor patterns revealed that animals utilized similar motor programs to execute the same actions in response to different cues but modified the motor programs during reversal learning. Our study demonstrates that mice can perform meta-learning tasks in VR, thus opening up opportunities for future mechanistic studies.

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