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1 Janelia Publications

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    Gene Targeting and Transgenics
    10/16/15 | Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates.
    Liu Z, Yang C, Sugino K, Fu C, Liu L, Yao X, Lee LP, Lee T
    Science (New York, N.Y.). 2015 Oct 16;350(6258):317-20. doi: 10.1126/science.aad1886

    Neural stem cells show age-dependent developmental potentials, as evidenced by their production of distinct neuron types at different developmental times. Drosophila neuroblasts produce long, stereotyped lineages of neurons. We searched for factors that could regulate neural temporal fate by RNA-sequencing lineage-specific neuroblasts at various developmental times. We found that two RNA-binding proteins, IGF-II mRNA-binding protein (Imp) and Syncrip (Syp), display opposing high-to-low and low-to-high temporal gradients with lineage-specific temporal dynamics. Imp and Syp promote early and late fates, respectively, in both a slowly progressing and a rapidly changing lineage. Imp and Syp control neuronal fates in the mushroom body lineages by regulating the temporal transcription factor Chinmo translation. Together, the opposing Imp/Syp gradients encode stem cell age, specifying multiple cell fates within a lineage.

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