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1 Janelia Publications

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    Satou LabScientific Computing Software
    02/29/24 | The cell-type-specific spatial organization of the anterior thalamic nuclei of the mouse brain.
    Kapustina M, Zhang AA, Tsai JY, Bristow BN, Kraus L, Sullivan KE, Erwin SR, Wang L, Stach TR, Clements J, Lemire AL, Cembrowski MS
    Cell Reports. 2024 Feb 29;43(3):113842. doi: 10.1016/j.celrep.2024.113842

    Understanding the cell-type composition and spatial organization of brain regions is crucial for interpreting brain computation and function. In the thalamus, the anterior thalamic nuclei (ATN) are involved in a wide variety of functions, yet the cell-type composition of the ATN remains unmapped at a single-cell and spatial resolution. Combining single-cell RNA sequencing, spatial transcriptomics, and multiplexed fluorescent in situ hybridization, we identify three discrete excitatory cell-type clusters that correspond to the known nuclei of the ATN and uncover marker genes, molecular pathways, and putative functions of these cell types. We further illustrate graded spatial variation along the dorsomedial-ventrolateral axis for all individual nuclei of the ATN and additionally demonstrate that the anteroventral nucleus exhibits spatially covarying protein products and long-range inputs. Collectively, our study reveals discrete and continuous cell-type organizational principles of the ATN, which will help to guide and interpret experiments on ATN computation and function.

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