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1 Janelia Publications
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Gonen Lab
02/13/17 |
Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nature Methods. 2017 Feb 13;14(4):399-402. doi: 10.1038/nmeth.4178
Traditionally, crystallographic analysis of macromolecules has depended on large, well-ordered crystals, which often require significant effort to obtain. Even sizable crystals sometimes suffer from pathologies that render them inappropriate for high-resolution structure determination. Here we show that fragmentation of large, imperfect crystals into microcrystals or nanocrystals can provide a simple path for high-resolution structure determination by the cryoEM method MicroED and potentially by serial femtosecond crystallography.