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1 Janelia Publications

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    Lee (Albert) Lab
    06/20/14 | Whole-cell patch-clamp recordings in freely moving animals.
    Lee AK, Epsztein J, Brecht M
    Methods in Molecular Biology. 2014 Jun 20;1183:263-76. doi: 10.1007/978-1-4939-1096-0_17

    The patch-clamp technique and the whole-cell measurements derived from it have greatly advanced our understanding of the coding properties of individual neurons by allowing for a detailed analysis of their excitatory/inhibitory synaptic inputs, intrinsic electrical properties, and morphology. Because such measurements require a high level of mechanical stability they have for a long time been limited to in vitro and anesthetized preparations. Recently, however, a considerable amount of effort has been devoted to extending these techniques to awake restrained/head-fixed preparations allowing for the study of the input-output functions of neurons during behavior. In this chapter we describe a technique extending patch-clamp recordings to awake animals free to explore their environments.

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