The animal’s body is made of diverse cell-types that are neatly organized to form functional organs. Using advanced imaging and genomic tools, we devise new strategies to deconstruct mechanisms by which the 3D genome encodes precise spatial and temporal control of cell fates during animal development
It is amazing that a fertilized egg - a single cell carrying one copy of mom's and one copy of dad's DNA, is able to divide, differentiate and give rise to a new-born baby with trillions of cells and hundreds of cell types, setting up the body plan that enables each of us to thrive in the society.
As a long-standing research direction, our lab quantitatively analyzes gene regulatory mechanisms at the single-cell, single-molecule level to discover how stereotypical cell fate choices during normal development as well as altered states in diseases emerge from seemly stochastic molecular events in the cell. To achieve this goal, we devise new imaging strategies to decipher functional links between genome organization, TF dynamics and transcription in culture as well as in vivo.
Currently, we are looking for a postdoctoral researcher with a research background in genomics to complement our imaging based approaches. If you are interested, please feel free to contact me at liuz11 at janelia.hhmi.org
"Function follows form
at present while form
follows function in
- my take
TF target search dynamics