Main Menu (Mobile)- Block

Main Menu - Block

A resource for the antennal lobe provided by the connectome of glomerulus VA1v.

Our Research / Publications
janelia7_blocks-janelia7_biblio_header | block
eLife. 2018 Nov 01;7. doi: 10.7554/eLife.37550
View Article on
A resource for the antennal lobe provided by the connectome of glomerulus VA1v. Scheffer LabHess LabFlyEM
Horne JA, Langille C, McLin S, Wiederman M, Lu Z, Xu CS, Plaza SM, Scheffer LK, Hess HF, Meinertzhagen IA
janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Using FIB-SEM we report the entire synaptic connectome of glomerulus VA1v of the right antennal lobe in . Within the glomerulus we densely reconstructed all neurons, including hitherto elusive local interneurons. The -positive, sexually dimorphic VA1v included >11,140 presynaptic sites with ~38,050 postsynaptic dendrites. These connected input olfactory receptor neurons (ORNs, 51 ipsilateral, 56 contralateral), output projection neurons (18 PNs), and local interneurons (56 of >150 previously reported LNs). ORNs are predominantly presynaptic and PNs predominantly postsynaptic; newly reported LN circuits are largely an equal mixture and confer extensive synaptic reciprocity, except the newly reported LN2V with input from ORNs and outputs mostly to monoglomerular PNs, however. PNs were more numerous than previously reported from genetic screens, suggesting that the latter failed to reach saturation. We report a matrix of 192 bodies each having 50 connections; these form 88% of the glomerulus' pre/postsynaptic sites.

PMID: 30382940 [PubMed - indexed for MEDLINE]

node:body | entity_field
janelia7_blocks-janelia7_biblio_authors | block

Janelia Authors

C. Shan Xu
Louis Scheffer
Harald Hess
janelia7_blocks-janelia7_biblio_tools | block