Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila.

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Neuron. 2018 Sep 19;100(3):651-68. doi: 10.1016/j.neuron.2018.08.037

Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila. Aso LabBock LabRubin LabFlyLight

Dolan M, Belliart-Guérin G, Bates AS, Frechter S, Lampin-Saint-Amaux A, Aso Y, Roberts RJ, Schlegel P, Wong A, Hammad A, Bock D, Rubin GM, Preat T, Placais P, Jefferis GS

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Abstract

The behavioral response to a sensory stimulus may depend on both learned and innate neuronal representations. How these circuits interact to produce appropriate behavior is unknown. In Drosophila, the lateral horn (LH) and mushroom body (MB) are thought to mediate innate and learned olfactory behavior, respectively, although LH function has not been tested directly. Here we identify two LH cell types (PD2a1 and PD2b1) that receive input from an MB output neuron required for recall of aversive olfactory memories. These neurons are required for aversive memory retrieval and modulated by training. Connectomics data demonstrate that PD2a1 and PD2b1 neurons also receive direct input from food odor-encoding neurons. Consistent with this, PD2a1 and PD2b1 are also necessary for unlearned attraction to some odors, indicating that these neurons have a dual behavioral role. This provides a circuit mechanism by which learned and innate olfactory information can interact in identified neurons to produce appropriate behavior.

PMID: 30244885 [PubMed - indexed for MEDLINE]

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Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila.

Abstract

PMID: 30244885 [PubMed - indexed for MEDLINE]

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