Main Menu (Mobile)- Block

Main Menu - Block

Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus

Our Research / Publications
janelia7_blocks-janelia7_biblio_header | block
Neuron. 2021 Oct 14;. doi: https://doi.org/10.1101/2021.06.30.450574
View Article on
Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus Spruston Lab
Zhao Xinyu, Hsu Ching-Lung, Spruston Nelson
janelia7_blocks-janelia7_biblio_abstract | block

Abstract

To successfully perform goal-directed navigation, animals must know where they are and what they are doing—e.g., looking for water, bringing food back to the nest, or escaping from a predator. Hippocampal neurons code for these critical variables conjunctively, but little is known about how this where/what code is formed or flexibly routed to other brain regions. To address these questions, we performed intracellular whole-cell recordings in mouse CA1 during a cued, two-choice virtual navigation task. We demonstrate that plateau potentials in CA1 pyramidal neurons rapidly strengthen synaptic inputs carrying conjunctive information about position and choice. Plasticity-induced response fields were modulated by cues only in animals previously trained to collect rewards based on these cues. Thus, we reveal that gradual learning is required for the formation of a conjunctive population code, upstream of CA1, while plateau-potential-induced synaptic plasticity in CA1 enables flexible routing of the code to downstream brain regions.

PMID: 34678146 [PubMed - indexed for MEDLINE]

node:body | entity_field

Previous bioRxiv PrePrint https://doi.org/10.1101/2021.06.30.450574

janelia7_blocks-janelia7_biblio_authors | block

Janelia Authors

Xinyu Zhao
Nelson Spruston
janelia7_blocks-janelia7_biblio_tools | block