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2 Janelia Publications

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    Spruston Lab
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    10/23/07 | Dendritic spikes induce single-burst long-term potentiation.
    Remy S, Spruston N
    Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 23;104(43):17192-7. doi: 10.1073/pnas.0707919104

    The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a candidate mechanism for learning, it is typically induced by using repeated synaptic activation to produce precisely timed, high-frequency, or rhythmic firing. Here we show that hippocampal synapses potentiate robustly in response to strong activation by a single burst. The induction mechanism of this single-burst LTP requires activation of NMDA receptors, L-type voltage-gated calcium channels, and dendritic spikes. Thus, dendritic spikes are a critical trigger for a form of LTP that is consistent with the function of the hippocampus in episodic memory.

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    Karpova LabTervo Lab
    10/01/07 | Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo.
    Tervo D, Karpova AY
    Current Opinion in Neurobiology. 2007 Oct;17(5):581-6. doi: 10.1016/j.conb.2007.10.002

    Inducible and reversible perturbation of the activity of selected neurons in vivo is critical to understanding the dynamics of brain circuits. Several genetically encoded systems for rapid inducible neuronal silencing have been developed in the past few years offering an arsenal of tools for in vivo experiments. Some systems are based on ion-channels or pumps, others on G protein coupled receptors, and yet others on modified presynaptic proteins. Inducers range from light to small molecules to peptides. This diversity results in differences in the various parameters that may determine the applicability of each tool to a particular biological question. Although further development would be beneficial, the current silencing tool kit already provides the ability to make specific perturbations of circuit function in behaving animals.

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