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3 Janelia Publications

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    01/06/25 | A split-GAL4 driver line resource for Drosophila neuron types
    Meissner GW, Vannan A, Jeter J, Close K, Depasquale GM, Dorman Z, Forster K, Beringer JA, Gibney TV, Hausenfluck JH, He Y, Henderson K, Johnson L, Johnston RM, Ihrke G, Iyer N, Lazarus R, Lee K, Li H, Liaw H, Melton B, Miller S, Motaher R, Novak A, Ogundeyi O, Petruncio A, Price J, Protopapas S, Tae S, Taylor J, Vorimo R, Yarbrough B, Zeng KX, Zugates CT, Dionne H, Angstadt C, Ashley K, Cavallaro A, Dang T, Gonzalez GA, Hibbard KL, Huang C, Kao J, Laverty T, Mercer M, Perez B, Pitts S, Ruiz D, Vallanadu V, Zheng GZ, Goina C, Otsuna H, Rokicki K, Svirskas RR, Cheong HS, Dolan M, Ehrhardt E, Feng K, El Galfi B, Goldammer J, Huston SJ, Hu N, Ito M, McKellar C, minegishi r, Namiki S, Nern A, Schretter CE, Sterne GR, Venkatasubramanian L, Wang K, Wolff T, Wu M, George R, Malkesman O, Aso Y, Card GM, Dickson BJ, Korff W, Ito K, Truman JW, Zlatic M, Rubin GM
    11/20/24 | Social state gates vision using three circuit mechanisms in Drosophila
    Catherine E. Schretter , Tom Hindmarsh Sten , Nathan Klapoetke , Mei Shao , Aljoscha Nern , Marisa Dreher , Daniel Bushey , Alice A. Robie , Adam L. Taylor , Kristin M. Branson , Adriane Otopalik , Vanessa Ruta , Gerald M. Rubin
    Nature. 2024 Nov 20:. doi: 10.1038/s41586-024-08255-6

    Animals are often bombarded with visual information and must prioritize specific visual features based on their current needs. The neuronal circuits that detect and relay visual features have been well studied. Much less is known about how an animal adjusts its visual attention as its goals or environmental conditions change. During social behaviours, flies need to focus on nearby flies. Here we study how the flow of visual information is altered when female Drosophila enter an aggressive state. From the connectome, we identify three state-dependent circuit motifs poised to modify the response of an aggressive female to fly-sized visual objects: convergence of excitatory inputs from neurons conveying select visual features and internal state; dendritic disinhibition of select visual feature detectors; and a switch that toggles between two visual feature detectors. Using cell-type-specific genetic tools, together with behavioural and neurophysiological analyses, we show that each of these circuit motifs is used during female aggression. We reveal that features of this same switch operate in male Drosophila during courtship pursuit, suggesting that disparate social behaviours may share circuit mechanisms. Our study provides a compelling example of using the connectome to infer circuit mechanisms that underlie dynamic processing of sensory signals.

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    07/13/17 | Mapping the neural substrates of behavior.
    Robie AA, Hirokawa J, Edwards AW, Umayam LA, Lee A, Phillips ML, Card GM, Korff W, Rubin GM, Simpson JH, Reiser MB, Branson KM
    Cell. 2017-07-13;170(2):393-406. doi: 10.1016/j.cell.2017.06.032

    Assigning behavioral functions to neural structures has long been a central goal in neuroscience and is a necessary first step toward a circuit-level understanding of how the brain generates behavior. Here, we map the neural substrates of locomotion and social behaviors for Drosophila melanogaster using automated machine-vision and machine-learning techniques. From videos of 400,000 flies, we quantified the behavioral effects of activating 2,204 genetically targeted populations of neurons. We combined a novel quantification of anatomy with our behavioral analysis to create brain-behavior correlation maps, which are shared as browsable web pages and interactive software. Based on these maps, we generated hypotheses of regions of the brain causally related to sensory processing, locomotor control, courtship, aggression, and sleep. Our maps directly specify genetic tools to target these regions, which we used to identify a small population of neurons with a role in the control of walking.

    •We developed machine-vision methods to broadly and precisely quantify fly behavior•We measured effects of activating 2,204 genetically targeted neuronal populations•We created whole-brain maps of neural substrates of locomotor and social behaviors•We created resources for exploring our results and enabling further investigation

    Machine-vision analyses of large behavior and neuroanatomy data reveal whole-brain maps of regions associated with numerous complex behaviors.

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