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2 Publications

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    Truman LabRiddiford Lab
    06/02/06 | Juvenile hormone is required to couple imaginal disc formation with nutrition in insects.
    Truman JW, Hiruma K, Allee JP, Macwhinnie SG, Champlin DT, Riddiford LM
    Science . 2006 Jun 2;312(5778):1385-8. doi: 10.1126/science.1123652

    In starved larvae of the tobacco hornworm moth Manduca sexta, larval and imaginal tissues stop growing, the former because they lack nutrient-dependent signals but the latter because of suppression by juvenile hormone. Without juvenile hormone, imaginal discs form and grow despite severe starvation. This hormone inhibits the intrinsic signaling needed for disc morphogenesis and does so independently of ecdysteroid action. Starvation and juvenile hormone treatments allowed the separation of intrinsic and nutrient-dependent aspects of disc growth and showed that both aspects must occur during the early phases of disc morphogenesis to ensure normal growth leading to typical-sized adults.

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    06/02/06 | Transitive closure and metric inequality of weighted graphs: detecting protein interaction modules using cliques.
    Ding C, He X, Xiong H, Peng H, Holbrook SR
    International Journal of Data Mining and Bioinformatics. 2006 Jun 2;1:162-77. doi: 10.1007/s12021-010-9090-x

    We study transitivity properties of edge weights in complex networks. We show that enforcing transitivity leads to a transitivity inequality which is equivalent to ultra-metric inequality. This can be used to define transitive closure on weighted undirected graphs, which can be computed using a modified Floyd-Warshall algorithm. These new concepts are extended to dissimilarity graphs and triangle inequalities. From this, we extend the clique concept from unweighted graph to weighted graph. We outline several applications and present results of detecting protein functional modules in a protein interaction network.

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