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    Wang (Shaohe) Lab
    11/20/17 | Localized Lysosome Exocytosis Helps Breach Tissue Barriers
    Shaohe Wang , Kenneth M. Yamada
    Developmental Cell. 11/2017;43:377-378. doi: https://doi.org/10.1016/j.devcel.2017.11.005

    Cell invasion across basement membrane barriers is important in both normal development and cancer metastasis. In this issue of Developmental Cell, Naegeli et al. (2017) identify a mechanism for breaching basement membranes. Localized lysosome exocytosis fuels generation of large, invasive cellular protrusions that expand tiny basement membrane openings.

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