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    Pachitariu Lab
    08/01/20 | Arousal modulates retinal output.
    Schröder S, Steinmetz NA, Krumin M, Pachitariu M, Rizzi M, Lagnado L, Harris KD, Carandini M
    Neuron. 2020 Aug 01;107(3):487. doi: 10.1016/j.neuron.2020.04.026

    At various stages of the visual system, visual responses are modulated by arousal. Here, we find that in mice this modulation operates as early as in the first synapse from the retina and even in retinal axons. To measure retinal activity in the awake, intact brain, we imaged the synaptic boutons of retinal axons in the superior colliculus. Their activity depended not only on vision but also on running speed and pupil size, regardless of retinal illumination. Arousal typically reduced their visual responses and selectivity for direction and orientation. Recordings from retinal axons in the optic tract revealed that arousal modulates the firing of some retinal ganglion cells. Arousal had similar effects postsynaptically in colliculus neurons, independent of activity in the other main source of visual inputs to the colliculus, the primary visual cortex. These results indicate that arousal modulates activity at every stage of the mouse visual system.

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