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    Tebo Lab
    01/08/15 | Artificial metalloenzymes derived from three-helix bundles.
    Tebo AG, Pecoraro VL
    Current Opinion in Chemical Biology. 01/2015;25C:65 – 70. doi: 10.1016/j.cbpa.2014.12.034

    Three-helix bundles and coiled-coil motifs are well-established de novo designed scaffolds that have been investigated for their metal-binding and catalytic properties. Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal. Here we describe recent contributions in the de novo design of metalloenzymes based on three-helix bundles and coiled-coil motifs, focusing on non-heme systems for hydrolytic and redox chemistry.

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