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    Rubin Lab
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    07/01/82 | The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain-specific transposon family.
    Bingham PM, Kidwell MG, Rubin GM
    Cell. 1982 Jul;29(3):995-1004. doi: 10.1186/gb-2007-8-7-r145

    We have shown previously that four of five white mutant alleles arising in P-M dysgenic hybrids result from the insertion of strongly homologous DNA sequence elements. We have named these P elements. We report that P elements are present in 30-50 copies per haploid genome in all P strains examined and apparently are missing entirely from all M strains examined, with one exception. Furthermore, members of the P family apparently transpose frequently in P-M dysgenic hybrids; chromosomes descendant from P-M dysgenic hybrids frequently show newly acquired P elements. Finally, the strain-specific breakpoint hotspots for the rearrangement of the pi 2 P X chromosome occurring in P-M dysgenic hybrids are apparently sites of residence of P elements. These observations strongly support the P factor hypothesis for the mechanistic basis of P-M hybrid dysgenesis.

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