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    Simpson Lab
    04/27/01 | Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.
    Kramer SG, Kidd T, Simpson JH, Goodman CS
    Science. 2001 Apr 27;292(5517):737-40. doi: 10.1126/science.1058766

    Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning.

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