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    Harris LabMouseLight
    03/02/23 | Brain-wide neural activity underlying memory-guided movement
    Susu Chen , Yi Liu , Ziyue Wang , Jennifer Colonell , Liu D. Liu , Han Hou , Nai-Wen Tien , Tim Wang , Timothy Harris , Shaul Druckmann , Nuo Li , Karel Svoboda
    bioRxiv. 2023 Mar 02:. doi: 10.1101/2023.03.01.530520

    Behavior requires neural activity across the brain, but most experiments probe neurons in a single area at a time. Here we used multiple Neuropixels probes to record neural activity simultaneously in brain-wide circuits, in mice performing a memory-guided directional licking task. We targeted brain areas that form multi-regional loops with anterior lateral motor cortex (ALM), a key circuit node mediating the behavior. Neurons encoding sensory stimuli, choice, and actions were distributed across the brain. However, in addition to ALM, coding of choice was concentrated in subcortical areas receiving input from ALM, in an ALM-dependent manner. Choice signals were first detected in ALM and the midbrain, followed by the thalamus, and other brain areas. At the time of movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions. Our experiments provide the foundation for neural circuit models of decision-making and movement initiation.

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