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03/02/06 |
Making the grade with models of persistent activity.
Neuron. 2006 Mar 2;49(5):649-51. doi: 10.3389/fnana.2010.00147
Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computational approaches.