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102 Publications
Showing 101-102 of 102 resultsYour Criteria:
06/18/09 |
Which spatial partition trees are adaptive to intrinsic dimension?
Conference on Uncertainty in Artificial Intelligence. 2009 Jun 18:
Tjian Lab
01/06/09 |
Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.
Proceedings of the National Academy of Sciences of the United States of America. 2009 Jan 6;106(1):55-60. doi: 10.1073/pnas.1100640108
Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results establish a coactivator function of TAF4 and provide a strategy to dissect mechanisms of TFIID function in vivo.