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    Wang (Meng) Lab
    02/21/24 | RAL-1 signaling regulates lipid composition in .
    Wu Y, Lee M, Mutlu AS, Wang M, Reiner DJ
    MicroPubl Biol. 2024 Feb 21;2024:. doi: 10.17912/micropub.biology.001054

    Signaling by the Ral small GTPase is poorly understood . animals with constitutively activated RAL-1 or deficient for the inhibitory RalGAP, HGAP-1 /2, display pale intestines. Staining with Oil Red O detected decreased intestinal lipids in the deletion mutant relative to the wild type. Constitutively activated RAL-1 decreased lipid detected by stimulated Raman scattering (SRS) microscopy, a label-free method of detecting lipid by laser excitation and detection. A signaling-deficient missense mutant for RAL-1 also displayed reduced lipid staining via SRS. We conclude that RAL-1 signaling regulates lipid homeostasis, biosynthesis or storage in live animals.

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