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1 Janelia Publications

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    Clapham LabCryo-Electron Microscopy
    07/13/18 | Cryo-EM structure of the polycystin 2-l1 ion channel.
    Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE
    eLife. 2018 Jul 13;7:. doi: 10.7554/eLife.36931

    We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.

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