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1 Janelia Publications

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    Ji Lab
    04/27/15 | Label-free spectroscopic detection of membrane potential using stimulated Raman scattering.
    Liu B, Lee HJ, Zhang D, Liao C, Ji N, Xia Y, Cheng J
    Applied Physics Letters. 2015 Apr 27;106:173704. doi: 10.1063/1.4919104

    Hyperspectral stimulated Raman scattering microscopy is deployed to measure single-membrane vibrational spectrum as a function of membrane potential. Using erythrocyte ghost as a model, quantitative correlation between transmembrane potential and Raman spectral profile was found. Specifically, the ratio between the area under Raman band at ∼2930 cm−1 and that at ∼2850 cm−1 increased by ∼2.6 times when the potential across the erythrocyte ghost membrane varied from +10 mV to −10 mV. Our results show the feasibility of employing stimulated Raman scattering microscopy to probe the membrane potential without labeling.

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