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1 Janelia Publications

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    Looger Lab
    04/17/20 | Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b..
    Weber C, Zhou Y, Lee JG, Looger LL, Qian G, Ge C, Capel B
    Science. 2020 Apr 17;368(6488):303-306. doi: 10.1126/science.aaz4165

    In many reptiles, including the red-eared slider turtle (), sex is determined by ambient temperature during embryogenesis. We previously showed that the epigenetic regulator is elevated at the male-producing temperature and essential to activate the male pathway. In this work, we established a causal link between temperature and transcriptional regulation of We show that signal transducer and activator of transcription 3 (STAT3) is phosphorylated at the warmer, female-producing temperature, binds the locus, and represses transcription, blocking the male pathway. Influx of Ca, a mediator of STAT3 phosphorylation, is elevated at the female temperature and acts as a temperature-sensitive regulator of STAT3 activation.

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