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1 Janelia Publications
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11/01/11 |
A computational statistics approach for estimating the spatial range of morphogen gradients.
Development. 2011 Nov;138(22):4867-74. doi: 10.1242/dev.071571
A crucial issue in studies of morphogen gradients relates to their range: the distance over which they can act as direct regulators of cell signaling, gene expression and cell differentiation. To address this, we present a straightforward statistical framework that can be used in multiple developmental systems. We illustrate the developed approach by providing a point estimate and confidence interval for the spatial range of the graded distribution of nuclear Dorsal, a transcription factor that controls the dorsoventral pattern of the Drosophila embryo.