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1 Janelia Publications

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    Reiser LabRubin LabFlyEM
    04/18/24 | Connectome-driven neural inventory of a complete visual system
    Aljoscha Nern , Frank Loesche , Shin-ya Takemura , Laura E Burnett , Marisa Dreher , Eyal Gruntman , Judith Hoeller , Gary B Huang , Michal Januszewski , Nathan C Klapoetke , Sanna Koskela , Kit D Longden , Zhiyuan Lu , Stephan Preibisch , Wei Qiu , Edward M Rogers , Pavithraa Seenivasan , Arthur Zhao , John Bogovic , Brandon S Canino , Jody Clements , Michael Cook , Samantha Finley-May , Miriam A Flynn , Imran Hameed , Kenneth J Hayworth , Gary Patrick Hopkins , Philip M Hubbard , William T Katz , Julie Kovalyak , Shirley A Lauchie , Meghan Leonard , Alanna Lohff , Charli A Maldonado , Caroline Mooney , Nneoma Okeoma , Donald J Olbris , Christopher Ordish , Tyler Paterson , Emily M Phillips , Tobias Pietzsch , Jennifer Rivas Salinas , Patricia K Rivlin , Ashley L Scott , Louis A Scuderi , Satoko Takemura , Iris Talebi , Alexander Thomson , Eric T Trautman , Lowell Umayam , Claire Walsh , John J Walsh , C Shan Xu , Emily A Yakal , Tansy Yang , Ting Zhao , Jan Funke , Reed George , Harald F Hess , Gregory S X E Jefferis , Christopher Knecht , Wyatt Korff , Stephen M Plaza , Sandro Romani , Stephan Saalfeld , Louis K Scheffer , Stuart Berg , Gerald M Rubin , Michael B Reiser
    bioRxiv. 2024 Apr 18:. doi: 10.1101/2024.04.16.589741

    Vision provides animals with detailed information about their surroundings, conveying diverse features such as color, form, and movement across the visual scene. Computing these parallel spatial features requires a large and diverse network of neurons, such that in animals as distant as flies and humans, visual regions comprise half the brain’s volume. These visual brain regions often reveal remarkable structure-function relationships, with neurons organized along spatial maps with shapes that directly relate to their roles in visual processing. To unravel the stunning diversity of a complex visual system, a careful mapping of the neural architecture matched to tools for targeted exploration of that circuitry is essential. Here, we report a new connectome of the right optic lobe from a male Drosophila central nervous system FIB-SEM volume and a comprehensive inventory of the fly’s visual neurons. We developed a computational framework to quantify the anatomy of visual neurons, establishing a basis for interpreting how their shapes relate to spatial vision. By integrating this analysis with connectivity information, neurotransmitter identity, and expert curation, we classified the 53,000 neurons into 727 types, about half of which are systematically described and named for the first time. Finally, we share an extensive collection of split-GAL4 lines matched to our neuron type catalog. Together, this comprehensive set of tools and data unlock new possibilities for systematic investigations of vision in Drosophila, a foundation for a deeper understanding of sensory processing.

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