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2 Janelia Publications

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    Reiser LabFlyLightFly Functional ConnectomeFly Facility
    12/15/22 | Eye structure shapes neuron function in Drosophila motion vision
    Arthur Zhao , Eyal Gruntman , Aljoscha Nern , Nirmala A. Iyer , Edward M. Rogers , Sanna Koskela , Igor Siwanowicz , Marisa Dreher , Miriam A. Flynn , Connor W. Laughland , Henrique D.F. Ludwig , Alex G. Thomson , Cullen P. Moran , Bruck Gezahegn , Davi D. Bock , Michael B. Reiser
    bioRxiv. 2022 Dec 15:. doi: 10.1101/2022.12.14.520178

    Many animals rely on vision to navigate through their environment. The pattern of changes in the visual scene induced by self-motion is the optic flow1, which is first estimated in local patches by directionally selective (DS) neurons24. But how should the arrays of DS neurons, each responsive to motion in a preferred direction at a specific retinal position, be organized to support robust decoding of optic flow by downstream circuits? Understanding this global organization is challenging because it requires mapping fine, local features of neurons across the animal’s field of view3. In Drosophila, the asymmetric dendrites of the T4 and T5 DS neurons establish their preferred direction, making it possible to predict DS responses from anatomy4,5. Here we report that the preferred directions of fly DS neurons vary at different retinal positions and show that this spatial variation is established by the anatomy of the compound eye. To estimate the preferred directions across the visual field, we reconstructed hundreds of T4 neurons in a full brain EM volume6 and discovered unexpectedly stereotypical dendritic arborizations that are independent of location. We then used whole-head μCT scans to map the viewing directions of all compound eye facets and found a non-uniform sampling of visual space that explains the spatial variation in preferred directions. Our findings show that the organization of preferred directions in the fly is largely determined by the compound eye, exposing an intimate and unexpected connection between the peripheral structure of the eye, functional properties of neurons deep in the brain, and the control of body movements.

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    02/01/22 | A neural circuit linking learning and sleep in Drosophila long-term memory.
    Lei Z, Henderson K, Keleman K
    Nature Communications. 2022 Feb 01;13(1):609. doi: 10.1038/s41467-022-28256-1

    Animals retain some but not all experiences in long-term memory (LTM). Sleep supports LTM retention across animal species. It is well established that learning experiences enhance post-learning sleep. However, the underlying mechanisms of how learning mediates sleep for memory retention are not clear. Drosophila males display increased amounts of sleep after courtship learning. Courtship learning depends on Mushroom Body (MB) neurons, and post-learning sleep is mediated by the sleep-promoting ventral Fan-Shaped Body neurons (vFBs). We show that post-learning sleep is regulated by two opposing output neurons (MBONs) from the MB, which encode a measure of learning. Excitatory MBONs-γ2α'1 becomes increasingly active upon increasing time of learning, whereas inhibitory MBONs-β'2mp is activated only by a short learning experience. These MB outputs are integrated by SFS neurons, which excite vFBs to promote sleep after prolonged but not short training. This circuit may ensure that only longer or more intense learning experiences induce sleep and are thereby consolidated into LTM.

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