Data Application

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only electron microscopy (EM) enables complete, unbiased mapping of synaptic connectivity; however, the fly brain is too large for conventional EM. Researchers led by the Bock lab developed a custom high-throughput EM platform and imaged the entire brain of an adult female fly at synaptic resolution.

Neuroseq: Neural Cell Types in Fly and Mouse

A vast neural tracing effort by a team of Janelia scientists has upped the number of fully-traced neurons in the mouse brain by a factor of 10. In addition, researchers can now download and browse the data in three dimensions. 

Inside the mouse brain, individual neurons zigzag across hemispheres, embroider branching patterns, and, researchers have now discovered, can even spool out spindly fibers up to 45 centimeters long.

At the Hippocampus RNA-seq atlas site, you can interactively analyze and visualize RNA-seq data for all excitatory cell populations in the hippocampus at multiple levels of granularity. Analysis can be hypothesis-driven by supplying predetermined lists of genes, or the dataset can be explored in a gene discovery-based fashion using enrichment and/or differential expression queries. To get started, select the population(s) of excitatory cells you are interested in analyzing, choose your desired level of analysis, and follow the prompts.

At Janelia, the FlyEM Project is developing technology that will enable us to create a map of every neuron and synapse in the Drosophila nervous system, using novel approaches to electron microscopy (EM) as the foundation. Researchers can use the data offered here to map neural circuitry. 

The data presented on the Split-GAL4 collection site are the work of the Janelia FlyLight Project Team, the Descending Interneuron Project Team, and the laboratories of Gerald M.

The data presented on this site are the work of the Janelia FlyLight Project Team and the laboratories of Gerald M. Rubin, James W. Truman, Richard S. Mann, and Christopher Q. Doe.