When you are lost or disoriented, your brain uses cues from your surroundings – landmarks both near and far – to sort out where you are. The information gathered by your senses is transmitted by nerve cells, or neurons, to specific brain regions where the signal is routed through circuits and sent downstream to areas that essentially translate the information into behavior and get you back on track.
Have you ever pressed Silly Putty onto the funny pages of a newspaper, then stretched the transferred picture so it’s larger than the original cartoon? If so, you already have a basic understanding of how expansion microscopy (ExM), an innovative technique being used at Janelia and other labs across the country, works.
The fly room is usually pretty busy in the morning.
Seventeen years ago, at a restaurant in Boulder, Colorado, three scientists leaned over a table, deep in discussion about a sketch they’d just scribbled onto the back of a napkin. It didn’t show a biochemical pathway or molecular motif, but an idea for a facility where researchers could develop and access advanced technologies.
Janelia Research Campus started as an idea sketched on the back of a napkin. Today, it stands as a research campus where scientists ask, learn, and collaborate on some of neurobiology’s biggest unknowns. How did Janelia go from a concept to bustling campus? Part of the answer lies in the first group of scientists, the pioneers of our research, who took a chance on Janelia. They began to build the foundation of scientists, staff, visitors, and friends behind the collaborative culture that drives our science forward.
11/18/19 | Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution.
Hayworth KJ, Peale DR, Januszewski M, Knott G, Lu Z, Xu CS, Hess HF
Nature Methods. 2019 Nov 18;. doi:10.1038/s41592-019-0641-2
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The Medical Research Council Laboratory of Molecular Biology (MRC LMB) in Cambridge, England, was founded in 1947 and was the world’s leading molecular biology research center for a 30-year period between 1950 and 1980.