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    Gonen Lab
    08/01/11 | Secretins: dynamic channels for protein transport across membranes.
    Korotkov KV, Gonen T, Hol WG
    Trends in Biochemical Sciences. 2011 Aug;36(8):433-43. doi: 10.1016/j.tibs.2011.04.002

    Secretins form megadalton bacterial-membrane channels in at least four sophisticated multiprotein systems that are crucial for translocation of proteins and assembled fibers across the outer membrane of many species of bacteria. Secretin subunits contain multiple domains, which interact with numerous other proteins, including pilotins, secretion-system partner proteins, and exoproteins. Our understanding of the structure of secretins is rapidly progressing, and it is now recognized that features common to all secretins include a cylindrical arrangement of 12-15 subunits, a large periplasmic vestibule with a wide opening at one end and a periplasmic gate at the other. Secretins might also play a key role in the biogenesis of their cognate secretion systems.

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