custom | custom
Filter
facetapi-Q2b17qCsTdECvJIqZJgYMaGsr8vANl1n | block
Associated Lab
- Remove Jayaraman Lab filter Jayaraman Lab
- Looger Lab (1) Apply Looger Lab filter
- Remove Podgorski Lab filter Podgorski Lab
facetapi-PV5lg7xuz68EAY8eakJzrcmwtdGEnxR0 | block
Publication Date
facetapi-021SKYQnqXW6ODq5W5dPAFEDBaEJubhN | block
Type of Publication
- Remove Janelia filter Janelia
general_search_page-panel_pane_1 | views_panes
1 Publications
Showing 1-1 of 1 resultsYour Criteria:
02/08/20 |
A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies.
bioRxiv. 2020 Feb 8:. doi: https://doi.org/10.1101/2020.02.07.939504
Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein. iAChSnFR shows large fluorescence changes, rapid rise and decay kinetics, and insensitivity to most cholinergic drugs. iAChSnFR revealed large transients in a variety of slice and in vivo preparations in mouse, fish, fly and worm. iAChSnFR will be useful for the study of acetylcholine in all animals.