Filter
Associated Lab
- Betzig Lab (2) Apply Betzig Lab filter
- Bock Lab (1) Apply Bock Lab filter
- Branson Lab (1) Apply Branson Lab filter
- Cardona Lab (15) Apply Cardona Lab filter
- Remove Fetter Lab filter Fetter Lab
- Harris Lab (3) Apply Harris Lab filter
- Hess Lab (5) Apply Hess Lab filter
- Keleman Lab (1) Apply Keleman Lab filter
- Rubin Lab (1) Apply Rubin Lab filter
- Saalfeld Lab (3) Apply Saalfeld Lab filter
- Scheffer Lab (4) Apply Scheffer Lab filter
- Simpson Lab (2) Apply Simpson Lab filter
- Spruston Lab (1) Apply Spruston Lab filter
- Svoboda Lab (1) Apply Svoboda Lab filter
- Tjian Lab (1) Apply Tjian Lab filter
- Truman Lab (9) Apply Truman Lab filter
- Zlatic Lab (5) Apply Zlatic Lab filter
Associated Project Team
Publication Date
- 2018 (4) Apply 2018 filter
- 2017 (4) Apply 2017 filter
- 2016 (6) Apply 2016 filter
- 2015 (5) Apply 2015 filter
- 2014 (1) Apply 2014 filter
- 2013 (3) Apply 2013 filter
- 2012 (1) Apply 2012 filter
- 2011 (4) Apply 2011 filter
- 2010 (2) Apply 2010 filter
- 2009 (5) Apply 2009 filter
- 2008 (4) Apply 2008 filter
- 2007 (2) Apply 2007 filter
Type of Publication
41 Publications
Showing 41-41 of 41 resultsWnt signaling through Frizzled proteins guides posterior cells and axons in C. elegans into different spatial domains. Here we demonstrate an essential role for Wnt signaling through Ror tyrosine kinase homologs in the most prominent anterior neuropil, the nerve ring. A genetic screen uncovered cwn-2, the C. elegans homolog of Wnt5, as a regulator of nerve ring placement. In cwn-2 mutants, all neuronal structures in and around the nerve ring are shifted to an abnormal anterior position. cwn-2 is required at the time of nerve ring formation; it is expressed by cells posterior of the nerve ring, but its precise site of expression is not critical for its function. In nerve ring development, cwn-2 acts primarily through the Wnt receptor CAM-1 (Ror), together with the Frizzled protein MIG-1, with parallel roles for the Frizzled protein CFZ-2. The identification of CAM-1 as a CWN-2 receptor contrasts with CAM-1 action as a non-receptor in other C. elegans Wnt pathways. Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system.