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    Baker Lab
    09/06/91 | The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila.
    Baker B, Kuroda M, Kreber M, Ganetzky B
    Cell. 1991 Sep 6;66(5):935-48

    The maleless (mle) gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males. A predicted mle protein (MLE) contains seven short segments that define a superfamily of known and putative RNA and DNA helicases. MLE, while present in the nuclei of both male and female cells, differs in its association with polytene X chromosomes in the two sexes. MLE is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females. The predominant localization of MLE to the X chromosome in males makes it a strong candidate to be a direct regulator of dosage compensation.

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