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2 Publications

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    Wang (Meng) Lab
    01/02/24 | Cutting through stress.
    Jasper LA, Wang MC
    Nature Metabolism. 2024 Jan 02:. doi: 10.1038/s42255-023-00946-0
    Wang (Meng) Lab
    01/19/24 | Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
    Yong Yu , Shihong M. Gao , Youchen Guan , Pei-Wen Hu , Qinghao Zhang , Jiaming Liu , Bentian Jing , Qian Zhao , David M Sabatini , Monther Abu-Remaileh , Sung Yun Jung , Meng C. Wang
    eLife. 2024 Jan 19:. doi: 10.7554/eLife.85214

    Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins enriched at lysosomes mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling have been linked with longevity regulation; however, how lysosomes adjust their protein composition to accommodate this regulation remains unclear. Using large-scale proteomic profiling, we systemically profiled lysosome- enriched proteomes in association with different longevity mechanisms. We further discovered the lysosomal recruitment of AMPK and nucleoporin proteins and their requirements for longevity in response to increased lysosomal lipolysis. Through comparative proteomic analyses of lysosomes from different tissues and labeled with different markers, we discovered lysosomal heterogeneity across tissues as well as the specific enrichment of the Ragulator complex on Cystinosin positive lysosomes. Together, this work uncovers lysosomal proteome heterogeneity at different levels and provides resources for understanding the contribution of lysosomal proteome dynamics in modulating signal transduction, organelle crosstalk and organism longevity.

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