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    Sgro Lab
    08/15/08 | Single-synapse ablation and long-term imaging in live C. elegans.
    Allen PB, Sgro AE, Chao DL, Doepker BE, Scott Edgar J, Shen K, Chiu DT
    J Neurosci Methods. 09/2008;173(1):20-6. doi: 10.1016/j.jneumeth.2008.05.007

    Synapses are individually operated, computational units for neural communication. To manipulate physically individual synapses in a living organism, we have developed a laser ablation technique for removing single synapses in live neurons in C. elegans that operates without apparent damage to the axon. As a complementary technique, we applied microfluidic immobilization of C. elegans to facilitate long-term fluorescence imaging and observation of neuronal development. With this technique, we directly demonstrated the existence of competition between developing synapses in the HSNL motor neuron.

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