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1 Janelia Publications

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    Cryo-Electron Microscopy
    08/29/23 | Functionalization and higher-order organization of liposomes with DNA nanostructures.
    Zhang Z, Feng Z, Zhao X, Jean D, Yu Z, Chapman ER
    Nature Communications. 2023 Aug 29;14(1):5256. doi: 10.1038/s41467-023-41013-2

    Small unilamellar vesicles (SUVs) are indispensable model membranes, organelle mimics, and drug and vaccine carriers. However, the lack of robust techniques to functionalize or organize preformed SUVs limits their applications. Here we use DNA nanostructures to coat, cluster, and pattern sub-100-nm liposomes, generating distance-controlled vesicle networks, strings and dimers, among other configurations. The DNA coating also enables attachment of proteins to liposomes, and temporal control of membrane fusion driven by SNARE protein complexes. Such a convenient and versatile method of engineering premade vesicles both structurally and functionally is highly relevant to bottom-up biology and targeted delivery.

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