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Labs:
Project Teams:
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Fly Facility
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
2002
Näär AM, Taatjes DJ, Zhai W, Nogales E, Tjian R.
2002. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.. Genes & Development. 16(11):1339-44.
Freiman RN, Tjian R.
2002. Neurodegeneration. A glutamine-rich trail leads to transcription factors.. Science . 296(5576):2149-50.
Freiman RN, Albright SR, Chu LE, Zheng S, Liang H-E, Sha WC, Tjian R.
2002. Redundant role of tissue-selective TAF(II)105 in B lymphocytes.. Molecular and Cellular Biology. 22(18):6564-72.
Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R.
2002. Structure, function, and activator-induced conformations of the CRSP coactivator.. Science. 295(5557):1058-62.
Hochheimer A, Zhou S, Zheng S, Holmes MC, Tjian R.
2002. TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila.. Nature. 420(6914):439-45.
2003
Ladurner AG, Inouye C, Jain R, Tjian R.
2003. Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.. Molecular Cell. 11(2):365-76.
Puig O, Marr MT, M Ruhf L, Tjian R.
2003. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.. Genes & Development. 17(16):2006-20.
Hochheimer A, Tjian R.
2003. Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression.. Genes & Development. 17(11):1309-20.
Freiman RN, Tjian R.
2003. Regulating the regulators: lysine modifications make their mark.. Cell. 112(1):11-7.
Isogai Y, Tjian R.
2003. Targeting genes and transcription factors to segregated nuclear compartments.. Current Opinion in Cell Biology. 15(3):296-303.
Levine M, Tjian R.
2003. Transcription regulation and animal diversity.. Nature. 424:147-51.
2004
Taatjes DJ, Schneider-Poetsch T, Tjian R.
2004. Distinct conformational states of nuclear receptor-bound CRSP-Med complexes.. Nature Structural & Molecular Biology. 11(7):664-71.
Ziegelbauer J, Wei J, Tjian R.
2004. Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth.. Proceedings of the National Academy of Sciences of the United States of America. 101(2):458-63.
Wang Z, Zhai W, Richardson JA, Olson EN, Meneses JJ, Firpo MT, Kang C, Skarnes WC, Tjian R.
2004. Polybromo protein BAF180 functions in mammalian cardiac chamber maturation.. Genes & Development. 18(24):3106-16.
Taatjes DJ, Marr MT, Tjian R.
2004. Regulatory diversity among metazoan co-activator complexes.. Nature Reviews. Molecular Cell Biology. 5(5):403-10.
Taatjes DJ, Tjian R.
2004. Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex.. Molecular Cell. 14(5):675-83.
2005
Zhai W, Jeong H, Cui L, Krainc D, Tjian R.
2005. In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets.. Cell. 123(7):1241-53.
Falender AE, Freiman RN, Geles KG, Lo KC, Hwang KS, Lamb DJ, Morris PL, Tjian R, Richards JAS.
2005. Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID.. Genes & Development. 19(7):794-803.
Leschziner AE, Lemon B, Tjian R, Nogales E.
2005. Structural studies of the human PBAF chromatin-remodeling complex.. Structure. 13(2):267-75.
2006
Yang F, Vought BW, Satterlee JS, Walker AK, Sun Z-YJim, Watts JL, DeBeaumont R, R Saito M, Hyberts SG, Yang S et al..
2006. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.. Nature. 442(7103):700-4.
Geles KG, Freiman RN, Liu W-L, Zheng S, Voronina E, Tjian R.
2006. Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks.. Proceedings of the National Academy of Sciences of the United States of America. 103(8):2594-9.
Marr MT, Isogai Y, Wright KJ, Tjian R.
2006. Coactivator cross-talk specifies transcriptional output.. Genes & Development. 20(11):1458-69.
Grob P, Cruse MJ, Inouye C, Peris M, Penczek PA, Tjian R, Nogales E.
2006. Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.. Structure. 14(3):511-20.