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11 ResultsShowing 1-10 of 11 results
CaMPARI (Calcium Modulated Photoactivatable Ratiometric Integrator) is a photoconvertible protein construct that enables imaging of the integrated calcium activity of large populations of cells...
The second generation of CaMPARI molecules have several advantages over their predecessors. By mutating the amino acids in the photophore domain, researchers were able to improve green brightness...
The use of fluorescence technologies for biochemi-cal and biological research has exploded in recent years. Chemical fluorophores can enable super-resolution microscopy, high-throughput screening...
Chimeric Ligand-Gated Ion Channels
In the nervous system, ligand-gated ion channels (LGICs) transduce chemical signals into electrical activity that communicates information. Implicated in many neurological disorders, LGICs are...
Current Iterations: GCaMP3, GCaMP5, GCaMP6, jGCaMP7 Fluorescent calcium indicators are an important tool used to detect and measure calcium, an essential regulator of cellular signaling....
Inventors at Janelia have developed a strategy for the creation of genetically encoded, intensity-based fluorescent sensors and an associated unique set of analytical tools that can measure...
The major neurotransmitter in the brain, glutamate is an important signaling molecule in biological organisms. The ability to visualize and quantitate glutamate transients is broadly useful to...
Janelia Fluor® Dyes
Bright and photostable fluorescent labels are critical tools for the life sciences. A key determinant of fluorophore performance is the quantum yield (QY); dyes with improved QY values are...
An important challenge in neuroscience is mapping the synaptic connectivity of neuronal networks in mammalian brains. The presence and statistical characteristics of actual synaptic...
Related: see the description of jRCaMP1 here. A family of genetically encoded calcium indicators (GECIs) from fluorescent proteins other than Aquorea...