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    Tools
    CaMPARI
    CaMPARI (Calcium Modulated Photoactivatable Ratiometric Integrator) is a photoconvertible protein construct that enables imaging of the integrated calcium activity of large populations of cells...
    Tools
    Carbon-Based Fluorogenics
    The use of fluorescence technologies for biochemi-cal and biological research has exploded in recent years. Chemical fluorophores can enable super-resolution microscopy, high-throughput screening...
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    Chimeric Ligand-Gated Ion Channels
    In the nervous system, ligand-gated ion channels (LGICs) transduce chemical signals into electrical activity that communicates information. Implicated in many neurological disorders, LGICs are...
    Tools
    GCaMP
    Current Iterations: GCaMP3, GCaMP5, GCaMP6 Fluorescent calcium indicators are an important tool used to detect and measure calcium, an essential regulator of cellular signaling. These...
    Tools
    Glucose Sensor
    Inventors at Janelia have developed a strategy for the creation of genetically encoded, intensity-based fluorescent sensors and an associated unique set of analytical tools that can measure...
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    iGluSnFR
    The major neurotransmitter in the brain, glutamate is an important signaling molecule in biological organisms. The ability to visualize and quantitate glutamate transients is broadly useful to...
    Tools
    Janelia Fluor® Dyes
    Bright and photostable fluorescent labels are critical tools for the life sciences.  A key determinant of fluorophore performance is the quantum yield (QY); dyes with improved QY values are...
    Tools
    mGRASP
      An important challenge in neuroscience is mapping the synaptic connectivity of neuronal networks in mammalian brains. The presence and statistical characteristics of actual synaptic...
    Tools
    RCaMP Sensors
    Related: see the description of jRCaMP1 here.  A family of genetically encoded calcium indicators (GECIs) from fluorescent proteins other than Aquorea...
    Tools
    Single-Fluorescent Protein Biosensors
    Maltose Sensor - Glutamate Sensor - Phosphonate Sensor Inventors at Howard Hughes Medical Center’s Janelia Research Campus have produced a general strategy for the creation of...