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Optical imaging affords an entirely different approach to circuit level activity and anatomy. We have an active program, working closely with the GENIE Project, the Looger Lab, the Lavis Lab and the Schreiter Lab to characterize the photophysical properties of new dyes and fluorescent protein sensors for calcium, neurotransmitters, and membrane voltage.  Much of our work involves two-photon studies of calcium indicators that improve the imaging of neural activity in vivo, down to single action potentials.  We also have a considerable effort exploring photoswitchable and photoactivatable fluorescent proteins used in super-resolution microscopy, correlative optical/EM microscopy, and single-molecule imaging of cellular transcription and embryo development.