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1 Publications

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    Harris Lab
    02/13/20 | The Neuropixels probe: A CMOS based integrated microsystems platform for neuroscience and brain-computer interfaces.
    Dutta B, Trautmann EM, Welkenhuysen M, Shenoy KV, Andrei A, Harris TD, Lopez CM, O'Callahan J, Putzeys J, Raducanu BC, Severi S, Stavisky SD
    2019 IEEE International Electron Devices Meeting (IEDM). 2020 Feb 13:. doi: 10.1109/IEDM19573.201910.1109/IEDM19573.2019.8993611

    We review recent progress in neural probes for brain recording, with a focus on the Neuropixels platform. Historically the number of neurons’ recorded simultaneously, follows a Moore’s law like behavior, with numbers doubling every 6.7 years. Using traditional techniques of probe fabrication, continuing to scale up electrode densities is very challenging. We describe a custom CMOS process technology that enables electrode counts well beyond 1000 electrodes; with the aim to characterize large neural populations with single neuron spatial precision and millisecond timing resolution. This required integrating analog and digital circuitry with the electrode array, making it a standalone integrated electrophysiology recording system. Input referred noise and power per channel is 7.5µV and <50µW respectively to ensure tissue heating <1°C. This approach enables doubling the number of measured neurons every 12 months.

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