Imaging

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Overview:

A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms, and flies

Mapping the locations of RNA in cells and tissues is a valuable technique in biomedical research for understanding fundamental principles and developing assays. Several spatial omics techniques have demonstrated the significance of that knowledge: hybridization methods such as MERFISH and seqFISH, along with sequencing methods like FISSEQ and STARmap, have led to remarkable discoveries.

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Overview

HaloCaMP integrates circularly permuted HaloTag proteins with a range of Janelia Fluor (JF) dyes to form bright, modular calcium indicators for in vitro and in-cell imaging. This chemigenetic system offers far-red imaging, rapid labeling, and customizable readouts for neuroscience and cell biology.

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Overview 

Biotin-Janelia Fluor® conjugates are cell-permeable, fluorescent ligands designed for affinity purification using the HaloTag platform with easy confirmation using imaging. Drug-JF compounds can elicit the translocation of proteins to defined subcellular regions.

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Overview

BAPTA-JF indicators merge the superior properties of the Janelia Fluor® dyes, the Ca²⁺ sensitivity of BAPTA, and the genetic targeting precision of self-labeling tags like the HaloTag. This next-generation sensor platform delivers high-performance for both cellular and subcellular functional imaging.

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Overview

A versatile platform enabling the construction of dyes for super-resolution imaging by coupling a coumarin auxiliary to rhodamine dyes. Dyes can be tuned to be either photochromic, with 405 nm activation, or spontaneously blinking at physiological conditions, yielding a palette of dyes in different colors.

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Overview

Photoactivatable versions of Janelia Fluor® dyes combine the brightness and photostability of this small-molecule fluorophore platform with the spatial and temporal control of photoactivation, ideal for advanced imaging workflows.

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Overview

Fluorination and structural tuning of rhodamine scaffolds have yielded a powerful new class of bright, red-shifted fluorescent dyes for live-cell and super-resolution microscopy.