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MANC connectome

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MANC connectome
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With about 23,000 neurons, 10 million pre-synaptic sites, and 74 million post-synaptic densities, the male adult nerve cord (MANC) connectome is a densely reconstructed map of synaptic connections in the fruit fly nerve cord – a structure analogous to the human spinal cord that controls most of the fly’s motor functions. This complete, extensively annotated connectome of the adult ventral nerve cord can be used to investigate any neural circuit of interest. It was produced through a collaboration between the FlyEM Project Team at HHMI Janelia, the Cambridge Connectomics Group, and Google Research.

The MANC is a milestone in connectomics.  It captures more synaptic connectivity than any other public connectome at the time of its release in June 2023.  It is the first complete nerve cord connectome and the first connectome of a bilaterally complete region of the central nervous system of an adult animal. For these reasons the MANC connectome will be of significant interest to computational neuroscientists, graph theorists and others using quantitative methods to investigate the nervous system. For neurobiologists the MANC dataset has been richly annotated with cell type information at different granularity and also benefits from neurotransmitter predictions across the dataset. This will immediately allow existing hypotheses to be refuted or supported and many new hypotheses to be generated.  This dataset also complements a partially proofread female VNC connectome (FANC) from Harvard, allowing for future detailed comparison of male and female premotor circuits.



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Funding for the MANC project was provided by HHMI, Wellcome Trust, University of Cambridge, Google Research, and the MRC Laboratory of Molecular Biology.