This unique meeting will bring together directors of imaging centers and program leaders of open access infrastructures. Our goal is to create a platform to explore the frontiers in imaging technologies, discuss common challenges, and strategize how the global imaging community can build a common network to tackle the era of “big data” as well as rapid technological advances in microscopy.View Full Details
How do distributed systems process and use information? How does one relate the coordinated, time-varying behavior of a system, whether it is a flock of animals, an ensemble of neurons, a network of genes, or a set of gates on a circuit board, to the underlying processing individual components, and collectives, may be performing? Answering these questions is a central challenge for diverse fields from biology to engineering. Human intuition for how the different components of a complex and strongly coupled system can work collectively to achieve a computational goal is limited, hindering our understanding of these processes and our ability to design systems that have such architectural and functional features.View Full Details
Co-sponsored by NSF and Janelia, this meeting will bring together thought leaders to discuss how eukaryotes evolved and to explore new opportunities to accelerate understanding of their evolution. We will explore how the study of non-eukaryotic cells and basal eukaryotes can provide insight into the origins of eukaryotic cellular organization, organelles, and eukaryote-specific molecular pathways. Attendees will share key data emerging from genomics, proteomics, informatics, computational biology, structural biology and microscopy, and will highlight the most exciting opportunities for future research. We will discuss gaps in our knowledge and identify specific research areas where the development of new strategies, new methods and new tools would most rapidly propel our understanding of the origins and diversity of eukaryotic cellular processes. The program will include short (15 min) talks, poster sessions and breakout sessions to explore sub-topics in greater depth. Participants and organizers will produce a written summary of the opportunities and potential strategies to accelerate research on the evolution of eukaryotes.View Full Details
There exists a rich, foundational, history of investigating neural mechanisms of sensorimotor transformation in the insect ventral nerve cord (VNC). Recently, new methods for genetic manipulation, optical imaging, and large-scale anatomical reconstruction of neural circuits have been applied to study insect nervous systems.View Full Details
Neural circuits large and small implement transfer functions that combine sensory inputs and prior experience to choose a behavioral response. By studying the most convenient animal models —from the giant axon of the squid and the lobster's stomatogastric circuits to Aplysia's synapses and C. elegans' circuits — neuroscientists have stumbled upon some of the operating principles of the nervous system, which were then found to apply broadly across phyla.View Full Details
Dexterous behavior involves sensory processing, coordinate transformations, learning, planning, execution, and online corrections. The multitude of these underlying operations necessitates the involvement of diverse circuits within the brain. The neuronal basis for dexterous actions is being investigated in many model systems (including flies, rodents, monkeys, and humans) and with many experimental techniques (from single cell electrophysiology to whole brain imaging).View Full Details
The generation of cellular resolution connectomes is rapidly advancing with recent examples of wiring diagrams from a variety of neural circuits and species. Connectomes have the promise to constrain existing models of neural circuit function as well as to provide a basis for new theoretical models.View Full Details
Explore Outstanding Phenomena in Animal Behavior
Jointly hosted by Janelia and the Mathematical Sciences Research Institute (MSRI), this program will bring together 15-20 advanced PhD students with complementary expertise who are interested in working at the interface of mathematics and biology. Emphasis will be placed on linking behavior to neural dynamics and exploring the coupling between these processes and the natural sensory environment of the organism. The aim is to educate a new type of global scientist that will work collaboratively in tackling complex problems in cellular, circuit and behavioral biology by combining experimental and computational techniques with rigorous mathematics and physics.
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